'Jimmy Kimmel Live' on-air personality and the host of "Cousin Sal’s Sure Thing," Sal Iacono breaks down the world of gambling across a variety of sports, including NFL, NBA, NHL, UFC, boxing, wrestling, and competitive hot dog eating. Each week, Sal offers up odds analysis as well as his best bets, and brings on celebrities, Vegas experts, and his pack of degenerate friends, who are shameless about discussing their latest wins and losses (mostly losses).